Abnormal Embryogenesis: Cellular and Molecular Aspects by Patricia A. Martin-Deleon, Evelyn L. Shaver (auth.), T. V. PDF

By Patricia A. Martin-Deleon, Evelyn L. Shaver (auth.), T. V. N. Persaud (eds.)

ISBN-10: 9401166544

ISBN-13: 9789401166546

ISBN-10: 9401166560

ISBN-13: 9789401166560

The examine of start defects has assumed an significance even better now than long ago simply because mortality charges attributed to congenital anomalies have declined a ways under these for different motives of loss of life, similar to infectious and dietary illnesses. it really is expected that as many as 50% of all pregnancies terminate as miscarriages. within the majority of circumstances this can be the results of defective improvement. significant congenital malformations are present in no less than 2% of all liveborn babies, and 22% of all stillbirths and toddler deaths are linked to critical congenital anomalies. Teratological experiences of an experimental nature are neither moral nor justifiable in people. a number of investigations were conducted in laboratory animals and different experimental versions with a purpose to increase our figuring out of irregular intrauterine improvement. In under 20 years the sector of experimental teratology has complex phenomenally. due to the wide selection of data that's now gathering, it has develop into attainable to procure an perception into the motives, mechanisms, and prevention of delivery defects. although, significant paintings may be wanted sooner than those difficulties should be resolved. The comributions during this quantity comprise many of the more moderen and interesting observations at the mobile and molecular facets of developmental defects. it isn't just a documentation of the most recent experimental paintings, however it additionally exhibits new and critical parts for destiny research.

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Extra info for Abnormal Embryogenesis: Cellular and Molecular Aspects

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Science, 141, 810 12. Soukup, S. , Takacs, E. and Warkany, J. (1965). Chromosomal changes in rat embryos following X-irradiation. Cytogenetics, 4, 130 13. , Takacs, E. and Warkany, J. (1967). Chromosomal changes in embryos treated with various teratogens. J. Embryol. Exp. , 18,215 14. Joneja, M. and Ungthavorn, S. (1968). Chromosome aberrations in trypan blue induced teratogenesis in mice. Canad. J. Genet. , 10,91 15. Bell, L. , Roux, C. and Hurley, L. S. (1975). Chromosomal abnor- 25 ABNORMAL EMBRYOGENESIS: CELLULAR AND MOLECULAR ASPECTS 16.

S. Environmental Protection Agency. We wish to thank Dr M. Z. Hussain for valuable discussions regarding this work. We also wish to thank Dr T. Z. Liu, Ms Kimie Kagawa, Ms Jamie McManus Long, Ms Maximita Tolentino, Ms Helma Enriquez, Mr Fredrick M. von Dohlen and Mr K. R. Sorensen for their contributions to our studies, and Mrs Valerie Willwerth for her assistance in the preparation of this manuscript. References 1. Grobstein, C. (1961). Cell contact in relation to embryonic induction. Exp. Cell Res.

P. (1974). Teratogenicity of methotrexate in mice. Teratology, 9, 159 Nowell, P. C. (1964). Mitotic inhibition and chromosome damage by mitomycin in human leucocyte cultures. Exp. , 33, 445 Zakharov, A. F. and Egolina, N. A. (1972). Differential spiralization along mammalian mitotic chromosomes. I. BrdU-revealed differentiation in Chinese hamster chromosomes. Chromosoma, 38, 341 Kihlman, F. A. and Kronberg, D. (1975). Sister chromatid exchange in Vicia faba. I. Demonstration by modified fluorescence plus Giemsa (FPG) technique.

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Abnormal Embryogenesis: Cellular and Molecular Aspects by Patricia A. Martin-Deleon, Evelyn L. Shaver (auth.), T. V. N. Persaud (eds.)

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