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By Richard G. Cutler (auth.), John E. Johnson Jr. (eds.)

ISBN-10: 1475714300

ISBN-13: 9781475714302

ISBN-10: 1475714327

ISBN-13: 9781475714326

The getting older procedure, like such a lot (all?) issues within the universe, is a puzzle. it's any such primary prevalence, universal to all dwelling issues, that it sarcastically could be the most complex and complicated puzzle to resolve. There are, after all, puzzles enough in quantity to occupy all of the scientists and philosophers who've ever lived one thousand occasions over. but what different phenomenon impacts every body people up to getting older? interest concerning the ubiquity of getting older as a phenomenon, boosted maybe by way of an purely usual worry of that very same phenomenon as an indisputable manifes­ tation of our personal mortality, has resulted in the compilation of knowledge at the getting older procedure, that have amassed as speedily because the aged who may benefit from these information. lots of the medical facts at the biology of getting older are on the biochemical and physiological degrees, whereas relatively little info has been avail­ capable on the anatomical point. due to this, a two-volume set referred to as getting older and cellphone constitution used to be conceived, the 1st quantity having been released in 1981 and the second one quantity being released at the same time with the current one on mobilephone functionality. The emphasis on education of scientists and different contributors in complicated schooling has, in the course of prior a long time, been one in every of elevated specialization. no longer purely will we concentrate on body structure, anatomy, zoology, or literature, yet in glomerular filtration, synaptic junctions, tree frogs of Brazil, or English poetry of the 19th century.

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In several conversations with our colleagues from India, it was once instructed that we support to institute a sequence of symposia in India related in nature to those who were performed by means of our Latin American colleagues for greater than 10 years. We have been lucky to have with us in Oak Ridge Dr. Niyogi and Dr.

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It is therefore of interest to learn if changes in morphology, body size, and rates of development are governed by regulatory genes, like the proposed genetic processes governing LSP. Only a few genetic changes do indeed seem necessary to alter body size (both in relation to body size and brain size) and developmental rate. These changes, like the predicted changes governing the biochemical basis of longevity, appear to be governed by regulatory changes in genes. Much of the morphological changes occurring in human evolution can be explained by the principles of neoteny (Gould, 1977).

Thus, longevity of the human and other primate species may be due not to qualitative differences, as Sacher had suggested, but to quantitative differences in levels of gene products held in common in all mammalian species. Longevity difference in mammalian species might then simply be a matter of more of the same gene products that all species have in common. This idea was of considerable interest, for it was consistent with the postulate that longevity differences between species may evolve few biochemical differences.

Homunculus 0 Millions of years before present Figure 15. Evolution of longevity of the primate species along the hominid ancestral-descendant sequence leading to humans. Extinct species (0); living species (e). Numbers beside species are LSP estimates. Taken from Cutler (1976a). 0 ... ~ c Q) "0 Q. C o Q. 6 4 3 Log 10 (t ime, yrs) Figure 16. Evolution of longevity of the hominid species over the past 10 million years. Taken from Cutler (l976a). EVOLUTIONARY BIOLOGY c:: H. neondertholensis europoeus _ iii ...

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Aging and Cell Function by Richard G. Cutler (auth.), John E. Johnson Jr. (eds.)


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