Bodh I. Jugdutt's Aging and Heart Failure: Mechanisms and Management PDF

By Bodh I. Jugdutt

ISBN-10: 1493902679

ISBN-13: 9781493902675

ISBN-10: 1493902687

ISBN-13: 9781493902682

This booklet synthesizes the key examine advances in molecular, biochemical and translational features of getting older and middle failure over the past 4 a long time and addresses destiny instructions in administration and drug discovery. It offers medical concerns and molecular mechanisms relating to middle failure, together with the altering demographics within the getting older inhabitants with middle failure; high blood pressure and prevention of diastolic center failure within the getting older inhabitants; polypharmacy and hostile drug reactions within the getting older inhabitants with center failure; adjustments within the middle that accompany advancing age from people to molecules; aging-associated changes in myocardial irritation and fibrosis and aging-related adjustments in mitochondrial functionality and implications for center failure remedy. The e-book succinctly summarizes the massive quantity of knowledge on those key themes and highlights novel pathways that must be explored. that includes contributions from prime clinician-scientists, Aging and center Failure: Mechanisms and Management is an authoritative source at the significant medical concerns in middle failure remedy within the aged for cardiologists, gerontologists and internists.

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Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc Natl Acad Sci U S A. 1994;91:9857–60. 55. Oh H, Wang SC, Prahash A, et al. Telomere attrition and Chk2 activation in human heart failure. Proc Natl Acad Sci U S A. 2003;100:5378–83. 56. Njajou OT, Hsueh WC, Blackburn EH, et al. Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study. J Gerontol A Biol Sci Med Sci.

New York, NY: Raven; 1980. 47. Lakatta EG, Gerstenblith G, Weisfeldt ML. The aging heart: structure, function, and disease. In: Braunwald E, editor. Heart disease. Philadelphia, PA: Saunders; 1997. p. 1687–700. 48. Lakatta EG. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises. Part I. Circulation. 2003;107:139–46. 49. Lakatta EG. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises. Part II. Circulation. 2003;107:346–54. 50. Lakatta EG, Wang M, Najjar SS.

A second mechanism for telomere attrition involves inflammation. For example, stem cell cultures enriched with cytokines such as interleukin-6 (IL-6) and stem cell factor (SCF) show increased telomere attrition [29]. In a population of men and women aged 35–55 years and free of overt CV disease, increased levels of inflammation and oxidative stress markers such as IL-6 and hs-CRP (as well as fibrinogen in men and oxidized LDL and uric acid in both genders) were associated with shorter telomere lengths [36].

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Aging and Heart Failure: Mechanisms and Management by Bodh I. Jugdutt

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