Bodh I. Jugdutt's Aging and Heart Failure: Mechanisms and Management PDF
By Bodh I. Jugdutt
This booklet synthesizes the key examine advances in molecular, biochemical and translational features of getting older and middle failure over the past 4 a long time and addresses destiny instructions in administration and drug discovery. It offers medical concerns and molecular mechanisms relating to middle failure, together with the altering demographics within the getting older inhabitants with middle failure; high blood pressure and prevention of diastolic center failure within the getting older inhabitants; polypharmacy and hostile drug reactions within the getting older inhabitants with center failure; adjustments within the middle that accompany advancing age from people to molecules; aging-associated changes in myocardial irritation and fibrosis and aging-related adjustments in mitochondrial functionality and implications for center failure remedy. The e-book succinctly summarizes the massive quantity of knowledge on those key themes and highlights novel pathways that must be explored. that includes contributions from prime clinician-scientists, Aging and center Failure: Mechanisms and Management is an authoritative source at the significant medical concerns in middle failure remedy within the aged for cardiologists, gerontologists and internists.
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Additional resources for Aging and Heart Failure: Mechanisms and Management
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A second mechanism for telomere attrition involves inflammation. For example, stem cell cultures enriched with cytokines such as interleukin-6 (IL-6) and stem cell factor (SCF) show increased telomere attrition . In a population of men and women aged 35–55 years and free of overt CV disease, increased levels of inflammation and oxidative stress markers such as IL-6 and hs-CRP (as well as fibrinogen in men and oxidized LDL and uric acid in both genders) were associated with shorter telomere lengths .
Aging and Heart Failure: Mechanisms and Management by Bodh I. Jugdutt