New PDF release: Aging, Carcinogenesis, and Radiation Biology: The Role of

By Moselio Schaechter (auth.), Kendric C. Smith (eds.)

ISBN-10: 1475716621

ISBN-13: 9781475716627

ISBN-10: 1475716648

ISBN-13: 9781475716641

The covalent attachment to deoxyribonucleic acid in vivo of a big variety of forms of chemical substances (both common mobile materials comparable to proteins and amino acids, and likewise exogenous compounds resembling medicinal drugs, cancer agents, and so on. ) were proven to exert profound results upon cells. 4 learn activi­ ties, previously thought of to be completely self reliant, relate to this challenge of nucleic acid adducts--(1) general covalent attachment of DNA to membranes, protein linkers in chromosomes, and so on. ; (2) the jobs of radiation and chemical enhancement of DNA adduct formation in telephone killing and mutagenesis. (A similar box is using identified cross-linking reactions to achieve info on structural institutions in macromolecular complexes. ); (3) the relevance of DNA adducts to chemical and radiation carcinogenesis; (4) the rele­ vance of DNA adducts to the cross-linking concept of mobile getting older. (1) there are many examples of ordinary linkages among DNA and protein, e. g. , DNA-membrane attachment websites, protein linkers in chromosomes, amino acids covalently associated with DNA as a functionality of development stipulations, and gene law through non-covalently certain proteins. A precis of knowledge on typical adducts to DNA therefore serves to introduce the topic of the radiation and chemical enhancement of DNA adduct formation. (2) some time past, radiation biology has been involved as a rule with attempting to comprehend the radiation chemistry of purified DNA, and the organic results and service of those radiation-induced changes whilst produced in mobile DNA.

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1965, Isolation of high molecular weight DNA from Hemophilus influenzae, J. MoZ. BioZ. 11:476-490. , 1969, Structure of a pyrimidine amino acid from pea seedlings, Bioahim. Biophys. Aata 177:427-433. , 1964, Amino acid residues in deoxyribonucleic acids, Bioahim. Biophys. Aata 87:682-684. , 1963, Investigation of the purine sequences in deoxyribonucleic acids, Bioahim. Biophys. Aata 76:149-151. , 1968, Initiation of deoxyribonucleic acid replication at the nuclear membrane in human cells, J. MoZ.

1973, The anatomy of mitochondrial DNA: the localisatio n of the heat-induced and RNAse-induced scissions in the phosphodiester backbones, Eur. J. Bioahem. 40: 329-336. , 1975, Viscoelastic analysis of high molecular weight, alkali-den atured DNA from mouse 3T3 cell, Biophys. J. 15:233-237. , 1975, Viscoelastic characteri zation of single-stranded DNA from Esaheriahi a aoZi, Biophys. J. 15:223-232. , 1962, Nondegradative isolation of deoxyribonucleic acid in subunit form from calf thymus nuclei, Proa.

Not only do all DNAs have amino acids associated with them but the amounts and kinds bound to the DNA from a given source are reproducible. These amino acids are tissue and species specific and vary with the age and sex of the source (Salser and Balis, 1967, 1972). An early observation that the amount and kind of amino acids associated with bacterial DNA were influenced by the medium in which the bacteria were grown was suggestive of a possible function of these DNA-bound amino acids. , 1964; Webb, 1967).

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Aging, Carcinogenesis, and Radiation Biology: The Role of Nucleic Acid Addition Reactions by Moselio Schaechter (auth.), Kendric C. Smith (eds.)


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